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Record W2167552109 · doi:10.1016/s1474-4422(11)70175-2

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study

2011· article· en· W2167552109 on OpenAlexafffund
Owen A. Ross, Alexandra I. Soto‐Ortolaza, Michael G. Heckman, Jan Aasly, Nadine Abahuni, Grazia Annesi, Justin A. Bacon, Soraya Bardien, Maria Bozi, Alexis Brice, Laura Brighina, Christine Van Broeckhoven, Jonathan Carr, Marie‐Christine Chartier‐Harlin, Efthimios Dardiotis, Dennis W. Dickson, Nancy N. Diehl, Alexis Elbaz, Carlo Ferrarese, Alessandro Ferraris, Brian Fiske, J. Mark Gibson, Rachel A. Gibson, Georgios M. Hadjigeorgiou, Nobutaka Hattori, John P. A. Ioannidis, Barbara Jasińska‐Myga, Beom S. Jeon, Yun Joong Kim, Christine Klein, Rejko Krüger, Elli Kyratzi, Suzanne Lesage, Chin‐Hsien Lin, Timothy Lynch, Demetrius M. Maraganore, George D. Mellick, Eugénie Mutez, Christer Nilsson, Grzegorz Opala, Sung Sup Park, Andreas Puschmann, Aldo Quattrone, Manu Sharma, Peter A. Silburn, Young H. Sohn, Leonidas Stefanis, Vera Tadić, Jessie Theuns, Hiroyuki Tomiyama, Ryan J. Uitti, Enza Maria Valente, Simone van de Loo, Demetrios K. Vassilatis, Carles Vilariño‐Güell, Linda R. White, Karin Wirdefeldt, Zbigniew K. Wszołek, Ruey‐Meei Wu, Matthew J. Farrer

Bibliographic record

VenueThe Lancet Neurology · 2011
Typearticle
Languageen
FieldMedicine
TopicParkinson's Disease Mechanisms and Treatments
Canadian institutionsUniversity of British Columbia
FundersNational Institute of Environmental Health SciencesNational Institute of Neurological Disorders and StrokeYonsei University College of MedicineMedical Research CouncilInstituut Born-BungeCentre hospitalier régional universitaire de LilleVlaamse regeringSkånes universitetssjukhusŚląski Uniwersytet Medyczny w KatowicachCentralsjukhuset KristianstadSvenska LäkaresällskapetUniversiteit AntwerpenBijzonder Onderzoeksfonds UGentAssociation France ParkinsonKungliga Fysiografiska Sällskapet i LundSvenska Sällskapet för Medicinsk ForskningVetenskapsrådetParkinsonfondenUniversitair Ziekenhuis AntwerpenMinistero della SaluteUniversità degli Studi di Milano-BicoccaBelgian Federal Science Policy OfficeAFA FörsäkringKarolinska InstitutetUniversity of ThessalyInstitut National de la Santé et de la Recherche MédicaleUniwersytet Śląski w KatowicachYonsei UniversityFondation de FranceBundesministerium für Bildung und ForschungGriffith UniversityHermann und Lilly Schilling-Stiftung für Medizinische ForschungCanada Excellence Research Chairs, Government of CanadaAgence Nationale de la RechercheSouth African Medical Research CouncilEli Lilly and CompanyFonds Wetenschappelijk OnderzoekGenome British ColumbiaLunds UniversitetNational Institutes of HealthVolkswagen FoundationMichael J. Fox Foundation for Parkinson's Research
KeywordsLRRK2Odds ratioParkinson's diseaseGeneticsGenotypingHaplotypeMinor allele frequencyParkinsonismAlleleCase-control studyDiseaseAllele frequencyGenetic associationSingle-nucleotide polymorphismMedicineBiologyGenotypeInternal medicineGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.004
Meta-epidemiology (narrow)0.0010.002
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0010.002
Science and technology studies0.0020.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.270
Teacher spread0.238 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations344
Published2011
Admission routes2
Has abstractno

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