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The electrophysiological basis of MAP recordings

2005· letter· en· W2167589186 on OpenAlexaff
Edward J. Vigmond

Bibliographic record

VenueCardiovascular Research · 2005
Typeletter
Languageen
FieldMedicine
TopicCardiac electrophysiology and arrhythmias
Canadian institutionsUniversity of Calgary
Fundersnot available
KeywordsElectrophysiologyNeuroscienceMedicineComputer scienceInternal medicinePsychology

Abstract

fetched live from OpenAlex

Recently, differing views as to the genesis of monophasic action potential (MAP) recordings have surfaced [1–3]. Kondo et al. [1,3] claim that MAP recordings come about because core conductor theory dictates that the extracellular potential is a scaled version of the transmembrane voltage and that the contact electrode acts as a stationary ground. Franz [2] holds to the view that injury currents at the boundary of the contact electrode zone of influence lead to extracellular potential changes which reflect changes in transmembrane voltage. As a consequence of these divergent views, the importance of one electrode with respect to the other has come into question. MAP electrodes are similar to potentials recorded with the sucrose gap technique [4]. That is, the technique functions as MAP recordings do, indirectly measuring transmembrane voltage by differencing extracellular potentials. Due to its relative simplicity, this technique warrants further consideration to determine if similar physics concepts are at work, which may shed light on the present issue. The sucrose gap technique separates two portions of an active cable with a perfusion of sucrose solution that serves to stop propagation of any activity across the gap due to the high resistivity of the sucrose region. The intracellular domains are still connected. By taking the difference in extracellular potentials on opposite sides of the sucrose gap, an approximation of the transmembrane voltage is obtained. …

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesResearch integrity
Consensus categoriesResearch integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.430
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.004
Bibliometrics0.0000.001
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.008
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.045
GPT teacher head0.323
Teacher spread0.278 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations28
Published2005
Admission routes1
Has abstractyes

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