Evaluating the Anticancer Activity of Hedyotis diffusa Water Extract Against Human Breast Cancer MCF7 Cells
Bibliographic record
Abstract
Hedyotis diffusa has been used to treat cancers in traditional Chinese medicine for many years. Recently, several anthraquinone compounds were extracted from Hedyotis diffusa and identified as its anticancer ingredients. These compounds are able to induce apoptosis in several types of cancer cells. In this study, we showed that the anticancer activity of Hedyotis diffusa was highly selective, possessing high cytotoxicity towards human breast cancer MCF7 cells but almost no cytotoxicity against the mammary epithelial MCF12A cells. The Hedyotis diffusa water extract also elevated the energy metabolism in both MCF12A and MCF7 cells; but the ATP/ADP ratio was still maintained at about 1.0 in the MCF12A cells to avoid either apoptosis or uncontrolled proliferation. In addition, Sheshecaojing, a health product of Hedyotis diffusa marketed in China, gave a dose-dependent cytotoxic response against the MCF7 cells.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".