Protective Role of Some Feed Additives against Dizocelpine Induced Oxidative Stress in Testes of Rabbit Bucks
Bibliographic record
Abstract
As optimization of farm animals reproductive performance is a main objective, the present study was, undertaken to investigate the possible protective effect of vitamin C, vitamin E and olive pomace against dizocilpine (MK-801) induced oxidative stress and its resultant alterations on antioxidant status, spermiogram, hormonal, enzyme markers and histomorphology of testes of rabbit bucks during first and second month of the experiment. For this purpose thirty six male New Zealand White rabbits bucks were equally and randomly divided into six groups (6 in each) namely control injected with 1.0 ml sterile saline; second group was injected by dizocilpine at a dose 0.1 mg/kg. intraperitoneally (i.p.) for 5 consecutive days, the third group was subjected to dizocilpine and supplemented with “vitamin C” (1 g/L of drinking water) 1 g contain 100 I.U. vit C, while the forth group was subjected to dizocilpine and supplemented with “vitamin E” (50 ml/100 L of drinking water,1ml contain 20 I.U. vit E,) and those of the fifth group were supplemented with “vitamin C” plus “vitamin E”. All five groups were fed the same basal diet, while the sixth group was subjected to dizocilpine and fed diet which contains olive cake meal (10%). Results in first month revealed (1) significant decrease in spermiogram, antioxidative parameters, testicular estradiol, testosterone, enzyme markers and clear pathological changes in testes of dizocilpine group; (2) Significant improvement in the measured parameters of groups subjected to dizocilpine and supplemented with “vitamin E”, “vitamin C” and olive pomace; (3) significant increase of all measured parameters in the “vitamin C” plus “vitamin E” supplemented group. On the other hand, results at second month showed no difference between all groups in these parameters. Conclusively, it was obvious that the supplementation with vitamin C or/and vitamin E and olive pomace to male rabbits exposed to oxidative stress was associated with improved spermiogram, anti-oxidative parameters, hormonal and testicular enzymatic activities.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".