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Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia
Willemijn J. Jansen, Rik Ossenkoppele, Dirk L. Knol, Betty M. Tijms, Philip Scheltens, Frans R.J. Verhey, Pieter Jelle Visser, Pauline Aalten, Dag Aarsland, Daniel Alcolea, M Alexander, Ina S. Almdahl, Steven E. Arnold, Inês Baldeiras, Henryk Barthel, Bart N.M. van Berckel, Kristen Bibeau, Kaj Blennow, David J. Brooks, Mark A. van Buchem, Vincent Camus, Enrica Cavedo, Kewei Chen, Gaël Chételat, Ann D. Cohen, Alexander Drzezga, Sebastiaan Engelborghs, Anne M. Fagan, Tormod Fladby, Adam Fleisher, Wiesje M. van der Flier, Lisa Ford, Stefan Förster, Juan Fortea, Nadia Foskett, Kristian Steen Frederiksen, Yvonne Freund‐Levi, Giovanni B. Frisoni, Lutz Froelich, Tomasz Gabryelewicz, Kiran Dip Gill, Olymbia Gkatzima, Estrella Gómez‐Tortosa, Mark Forrest Gordon, Timo Grimmer, Harald Hampel, Lucrezia Hausner, Sabine Hellwig, Sanna‐Kaisa Herukka, Helmut Hildebrandt, Lianna Ishihara, Adrian Ivanoiu, William J. Jagust, Peter Johannsen, Ramesh Kandimalla, Elisabeth Kapaki, Aleksandra Klimkowicz‐Mrowiec, William E. Klunk, Sebastian Köhler, Norman Koglin, Johannes Kornhuber, Milica G. Kramberger, Koen Van Laere, Susan Landau, Dong Young Lee, Mony J. de Leon, Viviana Lisetti, Alberto Lleó, Karine Madsen, Wolfgang Maier, Jan Marcusson, Niklas Mattsson, Alexandre de Mendonça, Olga Meulenbroek, Philipp T. Meyer, Mark A. Mintun, Vincent Mok, José Luís Molinuevo, Hanne M. Møllergård, John C. Morris, Barbara Mroczko, Stefan Van der Mussele, Duk L. Na, Andrew B. Newberg, Agneta Nordberg, Arto Nordlund, Gerald Novak, George P. Paraskevas, Lucilla Parnetti, Gayan Perera, Oliver Peters, Julius Popp, Sudesh Prabhakar, Gil D. Rabinovici, Inez H.G.B. Ramakers, Lorena Rami, Catarina R. Oliveira, Juha O. Rinne, Karen M. Rodrigue, Eloy Rodríguez‐Rodríguez, Catherine M. Roe, Uroš Rot, Christopher C. Rowe, Eckart Rüther, Osama Sabri, Pascual Sánchez‐Juan, Isabel Santana, Marie Sarazin, Johannes Schröder, Christin Schütte, Sang Won Seo, Femke Soetewey, Hilkka Soininen, Luiza Spiru, Hanne Struyfs, Charlotte E. Teunissen, Magda Tsolaki, Rik Vandenberghe, Marcel M. Verbeek, Victor L. Villemagne, Stephanie J. B. Vos, Linda J.C. van Waalwijk van Doorn, Gunhild Waldemar, Anders Wallin, Åsa K. Wallin, Jens Wiltfang, David A. Wolk, Marzena Zboch, Henrik Zetterberg
Bibliographic record
VenueJAMA · 2015
Typereview
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsnot available
FundersCilagJanssen PharmaceuticalsNational Institute of Biomedical Imaging and BioengineeringNational Institute on AgingKrajowy Naukowy Osrodek WiodacySahlgrenska AkademinNational Health and Medical Research CouncilMedical Research CouncilCharles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. LouisUniversity of California, San DiegoGenentechChinese University of Hong KongNational Institutes of HealthVlaamse regeringNational Research CentreAcademy of FinlandServierInnovative Medicines InitiativeUniwersytet Medyczny im. Piastów Slaskich we WroclawiuIndian Council of Medical ResearchRheinische Friedrich-Wilhelms-Universität BonnUniversität zu KölnSundhed og Sygdom, Det Frie ForskningsrådRégion NormandieUniversitatea de Medicină şi Farmacie "Carol Davila" BucureştiFondation pour la Recherche sur AlzheimerRadboud Universitair Medisch CentrumCenter for Translational Molecular MedicineEli Lilly and CompanyUniversidade de LisboaMerz PharmaceuticalsGöteborgs UniversitetEuropean Federation of Pharmaceutical Industries and AssociationsBayer HealthCareInstitut National de la Santé et de la Recherche MédicaleH. Lundbeck A/SUniversité Pierre et Marie CurieUniversidade de CoimbraTurun YliopistoDeutsches Zentrum für Neurodegenerative ErkrankungenBelgian Federal Science Policy OfficeRigshospitaletNational and Kapodistrian University of AthensEisaiLeids Universitair Medisch CentrumKuopion Yliopistollinen SairaalaKarolinska InstitutetLunds UniversitetFonds Wetenschappelijk OnderzoekDementia Collaborative Research Centres, AustraliaF. Hoffmann-La RocheUniversité de GenèveVrije Universiteit AmsterdamRadboud UniversiteitUniversität HeidelbergUniversiteit van AmsterdamYork UniversityUniversiteit LeidenSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungTechnische Universität MünchenImperial College LondonGentofte HospitalDeutsche ForschungsgemeinschaftU.S. Department of DefenseSamsungCommonwealth Scientific and Industrial Research OrganisationMinistero della SaluteJanssen Research and DevelopmentAstraZenecaCanadian Institutes of Health ResearchEuropean CommissionLui Che Woo Institute of Innovative MedicineAristotle University of ThessalonikiZonMwIXICOTurun Yliopistollinen KeskussairaalaPostgraduate Institute of Medical Education and Research, ChandigarhInstituto de Investigación Marqués de ValdecillaAvid RadiopharmaceuticalsPfizerEU Joint Programme – Neurodegenerative Disease ResearchSorbonne UniversitéUniversiteit AntwerpenNorthern California Institute for Research and EducationAlzheimer's AssociationScience and Industry Endowment FundUniversità degli Studi di PerugiaEuropean Regional Development FundSeoul National UniversityKU LeuvenUniversity of PittsburghUniversity of PennsylvaniaAgence Nationale de la RechercheBiogenBioClinicaCentro de Investigación Biomédica en Red sobre Enfermedades NeurodegenerativasItä-Suomen YliopistoEdith Cowan UniversityBundesministerium für Bildung und ForschungMedpaceSungkyunkwan UniversityEmory UniversityInstituto de Salud Carlos IIISynarcFoundation for the National Institutes of HealthUniversity of Southern CaliforniaGlaxoSmithKlineBristol-Myers SquibbAlzheimer's Disease Neuroimaging InitiativeLundbeckfondenAXA Research FundMeso Scale DiagnosticsMenzies Centre for Australian Studies, King's College London, University of LondonThomas Jefferson UniversityNational Science Foundation
KeywordsMedicineDementiaAmyloid (mycology)PathologyDisease
Abstract
OpenAlex records an abstract for this work, but it could not be fetched just now.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.017
metaresearch head score (Gemma)0.040
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.017
Threshold uncertainty score0.090
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.017 | 0.040 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.005 | 0.013 |
| Bibliometrics | 0.004 | 0.004 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.056
GPT teacher head0.383
Teacher spread0.327 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designSystematic review
Domainnot available
GenreReview
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations1,635
Published2015
Admission routes1
Has abstractyes