Dynamics of an HIV-1 therapy model of fighting a virus with another virus
Why this work is in the frame
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Bibliographic record
Abstract
In this paper, we rigorously analyse an ordinary differential equation system that models fighting the HIV-1 virus with a genetically modified virus. We show that when the basic reproduction ratio ℛ(0)<1, then the infection-free equilibrium E (0) is globally asymptotically stable; when ℛ(0)>1, E (0) loses its stability and there is the single-infection equilibrium E (s). If ℛ(0)∈(1, 1+δ) where δ is a positive constant explicitly depending on system parameters, then the single-infection equilibrium E (s) that is globally asymptotically stable, while when ℛ(0)>1+δ, E (s) becomes unstable and the double-infection equilibrium E (d) comes into existence. When ℛ(0) is slightly larger than 1+δ, E (d) is stable and it loses its stability via Hopf bifurcation when ℛ(0) is further increased in some ways. Through a numerical example and by applying a normal form theory, we demonstrate how to determine the bifurcation direction and stability, as well as the estimates of the amplitudes and the periods of the bifurcated periodic solutions. We also perform numerical simulations which agree with the theoretical results. The approaches we use here are a combination of analysis of characteristic equations, fluctuation lemma, Lyapunov function and normal form theory.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it