Bibliographic record
Abstract
Aims: Evaluation of natural antioxidant potential of Kalanchoe pinnata leaves attributable towards its therapeutic properties. Study Design:In vitro experiments to validate antioxidant potential in aqueous and lipid phase. Methodology:The aqueous-alcoholic whole leaf extract designated as KPE (K.pinnata extract) was subjected to comprehensive biochemical analysis to reveal its natural strength as an antioxidative agent.In lipid protection ability assay where lipid phase (preemulsion) was prepared using linoleic acid with Fe 2+ , Fe 3+ and Cu 2+ as stress-inducers, it's potential to protect against peroxyl radical induced damage in non aqueous environment was tested.Deoxy-D-ribose degradation assay in presence or absence of chelating agent (EDTA) was tested to reveal non site-specific and site-specific hydroxyl radical (OHº) scavenging potential respectively.Sodium nitroprusside based nitric oxide (NO) quenching activity and nitroblue tetrazolium reduction based superoxide radical scavenging potential were also estimated.Results: Total phenolic content of KPE was 28.4±2 μg mg -1 .In lipid protection ability assay it exhibited maximally restricted Fe 2+ induced amplification of peroxyl raical (ROOº) Original Research Articleat 10 mg mL -1 .It elicited a significant (P = .05)inhibition of lipid auto-oxidation by directly scavenging peroxyl radicals.In potassium ferrithiocyanate-based reducing power assay, KPE exhibited significantly higher potency as compared to the standard synthetic antioxidant butylated hydroxy toluene (BHT), in the range of 100-2000 µg mL -1 .The ability of KPE to interact at the level of generation of hydroxyl radicals was also tested with deoxy-D-ribose degradation assay that revealed a two-fold higher non site-specific OHº scavenging potential than its site-specific activity.In sodium nitroprusside based NO quenching assay KPE showed >50% quenching activity at 0.5 mg mL -1 .Conclusions: KPE is a rich source of anti-oxidative properties and has strong protective potential against oxidative stress in both aqueous and lipid phases.Hydroxyl radical scavenging assay showed KPE's ability to scavenge free radicals is more due to its reductive potency than its metal-chelation activity attributable towards its exploration in herbal drug discovery research.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".