The Genome of the Kinetoplastid Parasite, <i>Leishmania major</i>
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Abstract
Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.
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The record
- Venue
- Science
- Topic
- Research on Leishmaniasis Studies
- Field
- Medicine
- Canadian institutions
- Canada's Michael Smith Genome Sciences CentreGenome British ColumbiaBC Cancer Agency
- Funders
- National Institute of Allergy and Infectious DiseasesWellcome Trust
- Keywords
- BiologyGenePseudogeneGenomeGeneticsRNATranscription (linguistics)RNA polymerase IIRNA polymeraseTrypanosoma bruceiLeishmaniaGene expressionParasite hostingPromoter
- Has abstract in OpenAlex
- yes