Synthesis and stereochemistry of 6-membered ring phosphonates
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Background : Organophosphorus compounds have important industrial and biomedical applications as pharmaceutical and agrochemical agents, as well as transition state analogs for the production of monoclonal antibodies. Methods : Two diastereomers of a 6-membered ring, cyclic phenyl phosphonate were synthesized in 8 steps from 1,3-butanediol. Results : The stereochemistry of the diastereomers was elucidated on the basis of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:oasis="http://docs.oasis-open.org/ns/oasis-exchange/table" altimg="e1.gif" display="inline" overflow="scroll"><mml:msup><mml:mrow /><mml:mrow><mml:mn>3</mml:mn><mml:mn>1</mml:mn></mml:mrow></mml:msup></mml:math>P NMR signals, together with<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:oasis="http://docs.oasis-open.org/ns/oasis-exchange/table" altimg="e2.gif" display="inline" overflow="scroll"><mml:msup><mml:mrow /><mml:mrow><mml:mn>1</mml:mn></mml:mrow></mml:msup></mml:math>H NMR nuclear Overhauser effects (NOE) difference experiments. Conclusions : Such cyclic phosphonates may have utility serving as transition state analogs for the production of monoclonal antibodies.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it