Absence of Association of Type 2 Diabetes With <i>CAPN10</i> and <i>PC-1</i> Polymorphisms in Oji-Cree
Why this work is in the frame
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Bibliographic record
Abstract
In the Oji-Cree of Northern Ontario, we previously demonstrated that the private HNF1A S319 allele was strongly associated with type 2 diabetes (1), and that the PPARG Q12 allele was associated with both the earlier onset and presence of type 2 diabetes (2). However, HNF1A S319 and PPARG Q12 were present in only ∼60% of Oji-Cree subjects with type 2 diabetes, suggesting that other genetic determinants exist in this population. Recent reports have implicated CAPN10 (3), specifically the UCSNP-43 G allele (also called g.4852G) (4), and PC-1 , specifically the Q121 allele (5,6), as possible genetic determinants for type 2 diabetes. We thus evaluated the association of these alleles with type 2 diabetes in the Oji-Cree. …
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it