6-Hydroxydopamine lesions of nucleus accumbens core abolish amphetamine-induced conditioned activity
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Bibliographic record
Abstract
Environmental cues associated with drug experiences appear to play a critical role in drug dependence. We have previously reported that dopamine-depleting lesions of the nucleus accumbens medial shell inhibit amphetamine-conditioned place preference. Here, we examined the effects of analogous lesions on amphetamine-conditioned locomotor activity. Bilateral core, but not medial shell, lesions attenuated unconditioned locomotion and abolished the conditioned locomotor response. Taken with our previous results, these findings confirm a role for accumbens core in amphetamine-induced locomotor activity and suggest that the role of medial shell DA transmission in conditioned place preference is related to reward processing rather than conditioning in general.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it