Chronic heart rate reduction with ivabradine and prevention of atherosclerosis progression assessed using intravascular ultrasound
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Experimental data have shown that reduction in atherosclerosis progression can be obtained through chronic heart rate reduction. Heart rate is significantly correlated with the severity and progression of atherosclerosis on coronary angiography in patients. Limitation of the progression of atherosclerosis may therefore become an important therapeutic target of the specific heart rate reducing agent ivabradine. The ability of intravascular ultrasound (IVUS) to assess plaque burden precisely makes it the ideal tool for a clinical trial of progression and regression of atherosclerosis. The present article provides an overview of the design and of some methodological features of a clinical trial to assess the effects of ivabradine on the progression of coronary atherosclerosis, as assessed by IVUS.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it