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Record W2170739303 · doi:10.3945/ajcn.112.044545

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease

2013· review· en· W2170739303 on OpenAlexfundno aff
Joyce B. J. van Meurs, Guillaume Paré, Stephen M. Schwartz, Aditi Hazra, Toshiko Tanaka, Sita H. Vermeulen, Ioana Cotlarciuc, Xin Yuan, Anders Mälarstig, Stefania Bandinelli, Henk J. Blom, Constance Chen, Yii-Der Chen, Robert Clarke, Abbas Dehghan, Jeanette Erdmann, Luigi Ferrucci, Anders Hamsten, Albert Hofman, David J. Hunter, Anuj Goel, Andrew D. Johnson, Sekar Kathiresan, Ellen Kampman, Douglas P. Kiel, Lambertus A. Kiemeney, John C. Chambers, Peter Kraft, Jan Lindemans, Barbara McKnight, Christopher P. Nelson, Christopher J. O’Donnell, Bruce M. Psaty, Paul M. Ridker, Fernando Rivadeneira, Lynda M. Rose, Udo Seedorf, David S. Siscovick, Heribert Schunkert, Jacob Selhub, Per Magne Ueland, Péter Vollenweider, Gérard Waeber, Dawn Waterworth, Hugh Watkins, Jacqueline C.M. Witteman, Martin den Heijer, Paul F. Jacques, André G. Uitterlinden, Jaspal S. Kooner, Dan Rader, Muredach P. Reilly, Vincent Mooser, Daniel I. Chasman, Nilesh J. Samani, Kourosh R. Ahmadi

Bibliographic record

VenueAmerican Journal of Clinical Nutrition · 2013
Typereview
Languageen
FieldMedicine
TopicFolate and B Vitamins Research
Canadian institutionsnot available
FundersNational Institute on Minority Health and Health DisparitiesNational Center for Research ResourcesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute on AgingNational Heart, Lung, and Blood InstituteVersus ArthritisNational Institutes of HealthUniversity of LeicesterCanadian Institutes of Health ResearchNational Institute for Health and Care ResearchNational Center for Advancing Translational SciencesWellcome TrustBritish Heart FoundationNational Cancer InstituteCancer Research UK
KeywordsMethylenetetrahydrofolate reductaseGenome-wide association studyCoronary artery diseaseInternal medicineSingle-nucleotide polymorphismHomocysteineGenetic associationGeneticsGenotypeBiologyAlleleGenetic variationMedicineGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.003
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.050
GPT teacher head0.402
Teacher spread0.352 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations206
Published2013
Admission routes1
Has abstractno

Explore more

Same venueAmerican Journal of Clinical NutritionSame topicFolate and B Vitamins ResearchFrench-language works237,207