Sunitinib induced immune thrombocytopenia in patient with metastatic renal cell carcinoma
Bibliographic record
Abstract
Sunitinib (Sutent®: Pfizer, New York, NY, USA) is an oral multi-targeted tyrosine kinase inhibitor approved for first-line treatment of metastatic renal cell carcinoma (mRCC) and imatinib-resistant metastatic gastrointestinal stromal tumors (GIST). Common non hematological side effects secondary to sunitinib are: fatigue (74%), diarrhea (55%), nausea (54%), altered taste (43%), skin rash (40%), hand foot syndrome (30%) and hypertension (28%). Common hematological side effects are neutropenia (53%) and thrombocytopenia (38%) secondary to myelosuppression. Here-in, we present case report of patient with inoperable metastatic left renal cell carcinoma who developed immune-mediated thrombocytopenia secondary to sunitinib and recovered successfully after sunitinib withdrawal. Differnetial diagnosis of drug induced immune mediated thrombocytopenia secondary to sunitinib must be made by oncologists in patients on sunitinib presenting as thrombocytopenia and in these cases sunitinib can safely be withdrawn.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".