Human Pancreas Preservation Prior to Islet Isolation
Bibliographic record
Abstract
Islet transplantation has become a feasible treatment option for patients with type 1 diabetes mellitus after improvements regarding less diabetogenic immunosuppression and preparation of sufficient quantities of highly viable islets for transplantation. While the current techniques of multiorgan harvesting and transportation of organs to distant hospitals often result in 12 h or more of cold storage time before transplantation, University of Wisconsin (UW) solution has proven to be effective in pancreas preservation, leading to successful clinical whole pancreas transplantation, and human pancreatic grafts can be preserved by UW solution for periods exceeding 24 h. In the case of clinical islet transplantation, however, prolonged cold ischemia in UW solution before islet isolation significantly reduced recovery of viable islets, and it is still difficult to recover sufficient numbers of islets from a single cadaveric donor pancreas to achieve insulin independence after transplantation. Therefore, preservation of the pancreas has been an important factor in the subsequent success of clinical islet transplantation. We review pancreas preservation prior to islet isolation and discuss a two-layer (UW solution/perfluorochemical) cold storage method of the human pancreas as a potential method for pancreas rescue.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".