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Record W2173981867

The Need for Ethnically Diverse Stem Cell Donors

2015· article· en· W2173981867 on OpenAlexvenueno aff
Warren Fingrut

Bibliographic record

VenueUBC Faculty of Medicine medical journal · 2015
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer Genomics and Diagnostics
Canadian institutionsnot available
Fundersnot available
KeywordsEthnically diverseEthnic groupStem cellAttritionDiversity (politics)MedicineBiologyPolitical scienceGenetics
DOInot available

Abstract

fetched live from OpenAlex

A majority of patients who are in need of a stem cell transplant cannot find a suitable genetic match in their families, and rely on unrelated donors: individuals who have registered with a stem cell donor database. Many unrelated stem cell donor registries currently direct their donor-recruitment teams to target and recruit ethnically diverse individuals as stem cell donors. However, despite a large body of evidence in the literature highlighting the need for ethnically diverse stem cell donors, no resource exists which explains why building an ethnically diverse stem cell donor-database is important or needed. The purpose of this review article is to summarize evidence highlighting the extent of ethnic and racial disparities both on registries in North America and worldwide. Further, the author explains the multifactorial nature of this disparity, with contributing factors including ethnic differences in representation, genetic diversity, and attrition rates. This review aims to equip donor recruitment staff and volunteers with a resource to inform their recruitment efforts, and support them to target recruitment of ethnically diverse stem cell donors.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.008
Threshold uncertainty score0.027

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.007
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0000.002
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0080.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.038
GPT teacher head0.314
Teacher spread0.276 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations16
Published2015
Admission routes1
Has abstractyes

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