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Record W2181924451 · doi:10.26443/msurj.v7i1.100

Bayesian Models for Phylogenetic trees

2012· article· en· W2181924451 on OpenAlexaff
Clarence Leung

Bibliographic record

VenueMcGill Science Undergraduate Research Journal · 2012
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomics and Phylogenetic Studies
Canadian institutionsMcGill University
Fundersnot available
KeywordsMarkov chain Monte CarloComputer sciencePhylogenetic treePython (programming language)Bayesian probabilityTree (set theory)Biological dataGibbs samplingAlgorithmMachine learningData miningArtificial intelligenceMathematicsBiologyBioinformatics

Abstract

fetched live from OpenAlex


 
 
 Introduction: inferring genetic ancestry of different species is a current challenge in phylogenetics because of the immense raw biological data to be analyzed. computational techniques are necessary in order to parse and analyze all of such data in an efficient but accurate way, with many algorithms based on statistical principles designed to provide a best estimate of a phylogenetic topology. Methods: in this study, we analyzed a class of algorithms known as Markov Chain Monte Carlo (MCMC) algorithms, which uses Bayesian statistics on a biological model, and simulates the most likely evolutionary history through continuous random sampling. we combined this method with a python-based implementation on both artificially generated and actual sets of genetic data from the UCSC genome browser. results and discussion: we observe that MCMC methods provide a strong alternative to the more computationally intense likelihood algorithms and statistically weaker parsimony algorithms. given enough time, the MCMC algorithms will generate a phylogenetic tree that eventually converges to the most probable configuration
 
 

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesScience and technology studies
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.418
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0020.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.081
GPT teacher head0.361
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2012
Admission routes1
Has abstractyes

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