Induction of prostaglandin endoperoxide synthase 2 in the follicles of equine chorionic gonadotropinhuman chorionic gonadotropin treated prepubertal gilts
Bibliographic record
Abstract
Prostaglandin G/H synthase-2 (PGHS-2) is a key rate limiting enzyme in the prostaglandin (PG) biosynthetic pathway, and PG synthesis is required for ovulation in pigs. The objective of this study was to characterize the expression and regulation of PGHS-2 in porcine follicles prior to ovulation. The combination of equine chorionic gonadotropin (eCG; 750 IU) followed by human chorionic gonadotropin (hCG; 500 IU) 72 h later was used to induce ovulation in prepubertal gilts. Previous studies have shown that ovulation is generally induced between 40 and 44 h post-hCG in this model. Ovariectomies were performed at 0, 24, 30, 34 and 38 h post-hCG (n = 4 or 5 animals per time-point), and all follicles larger than 4 mm in diameter were isolated. The regulation of PGHS-1 and PGHS-2 proteins was studied by immunohistochemistry and Western blot analyses, whereas the regulation of PGHS-2 mRNA was studied by Northern blot. PG production was assessed by radioimmunoassay (RIA). (Abstract shortened by UMI.)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".