Drug-induced skin events in hospitalized patients in Tehran, Iran: a 6-year case series study
Why this work is in the frame
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Bibliographic record
Abstract
Introduction: Drug reactions are commonly seen in the skin but their frequency has not been determined in Tehran yet. We aimed to evaluate adverse cutaneous drug events (ACDE) in hospitalized patients. Material and methods: A 6-year case series study (from 2000 to 2006) including all hospitalized patients in two referral dermatology wards of Loghman-Hakim and Shohada Hospitals was performed. Results: A total of 54 patients (31 female and 23 males) were included. Adverse cutaneous drug events was slightly more frequent in females (1.34 : 1). Thirty three and 22% of the patients were in the age group of 31-40 and 41-50, respectively. The most commonly seen dermatoses were maculo-papular rashes (60%), erythroderma (10%), and urticaria (10%). Drugs most frequently associated with ACDE were anticonvulsants and antibiotics, with rates of 31 and 28%, respectively. No mortality due to ACDE was seen. In most of the patients (50%), the duration of hospitalization was 3-7 days. Most of the patients (74%) had no previous history of allergy. In most cases (65%), the adverse events began during the first day to first month after drug exposure. Conclusions: Although the prevalence of ACDE in this study was found to be lower than reported data in the literature suggest, the results confirm that ACDE is a notable public health concern. Early and rapid recognition of severe ACDE and prompt withdrawal of the offending drug are the most important actions to minimize morbidity associated with drug use.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it