Bibliographic record
Abstract
Dystroglycan and the integrins are two types of extracellular matrix receptors involved in astrocyte adhesion and migration. The molecular mechanisms that control their distribution to signaling platforms of the plasma membrane remain poorly understood. In the present study, we define four cell spreading stages for adherent astrocytes, termed stage 1 to 4, and defined by the state of spreading of the cell in culture. Immunocytochemistry analysis reveals that DG and integrins distribute differentially depending on the stage, and both receptors get recruited to leading edge of the cell, possibly to GM1-rich lipid rafts, in scratch-induced migration. Treatment of reactive astrocytes with cytochalasin-D or colchicine confirms that the formation of MT-rich protrusions is not actin-independent. However, cortical actin localization is independent of the polarized MT network. We confirm scratch-induced Cdc42/Rac1 activation early after wounding and further investigated the role of DG in Rho GTPases signaling. We conclude that ECM receptors localization is tightly regulated along with the cytoskeletal reorganization machinery in astrocyte proliferation.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".