Gender differential in apo E genotypes’ correlative tendency to dyslipidaemia responsiveness upon flaxseed oil administration in adult type 2 diabetic patients not meeting the 2008 Canadian Practice Guidelines
Bibliographic record
Abstract
Fasting blood serum lipid concentrations, low density lipoprotein (LDL) oxidation, hypertension, and various anthropometric measures such as waist circumference are important measures of coronary atherosclerosis risk in type 2 diabetics. Apo E genotypes, leptin and adiponectin, modify fasting blood serum lipid levels and thus the degree of atherosclerosis as assessed in part by c-reactive protein (CRP). Hypertension, LDL oxidation and increased waist circumference promote atherosclerosis and hence the risk of myocardial infarction. It was hypothesised that there would be apo E, adiponectin, leptin and gender driven differences in myocardial infarction risk including hypertension, various anthropometric measures, CRP levels and at least some of the lipid levels including their modulating levels of leptin and adiponectin as the result of the administration of flaxseed oil (60 mg/kg bodyweight/day of alpha-linolenic acid for 90 days) and that apo E genotype would play a role in lipid responsiveness to such flaxseed oil administration. The purpose of this study was to assess this hypothesis. The only significant change seen was a statistically significant drop in cholesterol only in females consuming flaxseed oil with correlative evidence of apo E genotypic influence on other lipid parameter responsiveness in males and females. The absence of change in leptin and adiponectin levels suggests that this change did not occur due to these, lipid modulating, adipocytokines. Dietary intakes of calories, oleic acid and alpha-linolenic acid were consistent for each gender/treatment group and therefore consistent with no change in waist circumference. It is concluded that flaxseed oil consumption at an alpha-linolenic acid level of 60 mg/kg body weight/day for three months has no impact on the cardiovascular disease risk factors studied in the overall population herein except for cholesterol in female type 2 diabetics consuming flaxseed oil. However, in certain apo E genotypes there was a greater sensitivity to change in lipid parameters.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".