BIOAVAILABILITY AND DISPOSITION KINETICS OF AMOXICILLIN
Bibliographic record
Abstract
OBJECTIVE: The study was planned to observe the bioavailability anddisposition kinetics of amoxicillin in adult rabbits (irrespective of sex) under healthy anddehydrated conditions. Design: Comparative. Place and duration of study: The study wasconducted at the department of pharmacology, University of Veterinary and Animal Sciences,Lahore from April 2013 to October 2013. Methodology: Initially all rabbits were weighed andtheir packed cell volume (PCV) and other biochemical parameters were observed under normalconditions. Bioavailability and disposition kinetics of amoxicillin (10mg/kg body weight) werestudied in normal rabbits following oral and intravenous route of drug administration. After 10days washout period, these rabbits were made dehydrated by keeping the animals off waterbut not food. The animals with 10% decrease in body weight were declared dehydrated. Theirparameters were again measured. Treated rabbits were administered amoxicillin orally andintravenously (10mg/kg body weight). Samples were drawn at prescribed time. Amoxicillinwas assessed in plasma by using microbiological assay method. Plasma concentration wasanalyzed using non compartmental method. Results: The water deprived or dehydrated rabbitsshowed a significant increase in the packed cell volume, blood glucose and plasma globulins ascompared to the normal rabbits. However, there was a significant (p<0.05 & p<0.01) decreasein body weight, total proteins, albumins and albumin globulin ratio of the dehydrated rabbits.The peak plasma concentration, volume of distribution and rate constant of elimination waslower in the dehydrated rabbits as compared to the normal rabbits. The plasma concentrationof amoxicillin after intravenous administration in dehydrated rabbits had a significant (p<0.05& p<0.01) larger area under curve, area under 1st moment curve, a longer half life and a largermean residence time. Conclusions: The study in the dehydrated rabbits indicated the need ofmodification of dosage regimen.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".