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Biomarkers as Inputs

2015· book-chapter· en· W2190389760 on OpenAlexaff
Steven Lehrer

Bibliographic record

VenueOxford University Press eBooks · 2015
Typebook-chapter
Languageen
FieldMedicine
TopicScience, Research, and Medicine
Canadian institutionsQueen's University
Fundersnot available
KeywordsSocioeconomic statusPsychologyBiologyData scienceComputer scienceMedicineEnvironmental healthPopulation

Abstract

fetched live from OpenAlex

Abstract This chapter provides an overview of research primarily within the discipline of economics that empirically examines how biomarkers influences specific health and socioeconomic outcomes. Since the role that biomarkers are hypothesized to play in the estimating equation differs across studies, a distinction is first made between two separate categories of biomarkers: biological time-varying measures such as hormones and biological time-invariant measures including DNA. Recent research in these two categories is then reviewed, focusing on studies that can present the most credible evidence of the role of specific biomarkers. Last, an emerging literature that focuses on the interactions between time-varying environmental conditions and time-invariant genetic factors is discussed. The chapter concludes by highlights three promising areas for future research and suggesting researchers should shift their attention away from investigating specific candidate genes to polygenic risk scores, as well as focus on genetic interactions with more aggregated rather than specific environmental influences.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.018
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.087
Threshold uncertainty score0.293

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.018
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.004
Science and technology studies0.0010.002
Scholarly communication0.0080.006
Open science0.0020.003
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0870.021

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.067
GPT teacher head0.285
Teacher spread0.218 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2015
Admission routes1
Has abstractyes

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