Further Progress in Understanding Fibrosing Mediastinitis
Bibliographic record
Abstract
A potential concern is the effect of exogenous flow on endogenous cardiac output.Assessment of this relationship is complex (12); however, it is unlikely that native cardiac output would perfectly adjust (increasing or decreasing) to match the induced ECMO flow variations.Thus, if _ VO 2 was dependent on _ DO 2 , we would expect to see some correlating fluctuation.This conclusion is reinforced by the fact that the pattern of _ DO 2 versus _ VO 2 in the full cohort was identical to that in two patients without endogenous cardiac output (Figure 1).Finally, although O 2 supply dependency has traditionally been proposed in patients with sepsis (1), careful delineation of _ DO 2 -_ VO 2 relationships in individual patients reveals no differences between patients with proven sepsis versus those without sepsis (6); patients in the current had elevated inflammatory markers (e.g., CRP .50 mg/L in most), suggesting important systemic inflammation (see Table E6).In summary, we studied the _ DO 2 -_ VO 2 relationships in hemodynamically resuscitated critically ill patients with evidence of systemic inflammation receiving VA ECMO and found _ VO 2 to be independent of _ DO 2 in the ranges studied.Clinical trial registered with www.clinicaltrials.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.003 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.003 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".