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Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study

2015· article· en· 849 citations· W2193716145 on OpenAlex· 10.1016/s1470-2045(15)00464-7

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.180
GPT teacher head0.430
Teacher spread
0.250 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
The Lancet Oncology
Topic
Multiple Myeloma Research and Treatments
Field
Medicine
Canadian institutions
Western UniversityLondon Health Sciences Centre
Funders
CilagOnyx PharmaceuticalsAmgenTakeda OncologySpectrum PharmaceuticalsArray BioPharmaJanssen PharmaceuticalsGenentechCelgeneSanofiBristol-Myers SquibbChugai Pharmaceutical
Keywords
CarfilzomibMedicineBortezomibDexamethasoneMultiple myelomaClinical endpointInternal medicineRefractory (planetary science)PopulationTolerabilityInterim analysisOncologySurgeryClinical trialAdverse effect
Has abstract in OpenAlex
no