Bibliographic record
Abstract
Cytokines play a role in the inflammatory process in colitis and may have therapeutic potential. Interleukin‐10 (IL‐10) has both immunomodulatory and anti‐inflammatory properties. IL‐10‐deficient mice develop intestinal inflammation with increased tissue levels of other cytokines, including tumour necrosis factor‐alpha. In patients with inflammatory bowel disease, impaired IL‐10 production by lamina propria T cells occurs and human recombinant IL‐10 improves clinical parameters in inflammatory bowel disease (eg, Crohn′s disease). There seem to be conflicting results in differing animal models, and the timing of administration of IL‐10 relative to onset of colitis may be critical, possibly due to rapid clearance of IL‐10. Interestingly, in IL‐10 gene‐deficient mice raised in germ‐free conditions, the intestinal inflammatory changes normally observed in conventional nongerm‐free conditions are not detected, suggesting a role for luminal bacteria in the pathogenesis of the inflammatory process.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.004 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".