Abstract P6-10-17: Psychosocial adjustment, cancer worry and perceived risk in 6-13 year old girls from breast cancer families
Bibliographic record
Abstract
Abstract Background: Many parents discuss familial and genetic risk of breast cancer (BC) with offspring. What girls know and perceive of BC risk and its psychosocial impact is unknown. Methods: In the multisite LEGACY Girls Study, 6-13 YO daughters and their parents/guardians from BC families (FH+) and families without BC (FH-) were recruited to examine early determinants of, and responses to BC risk. Parents/guardians completed surveys reporting on their daughters’ psychosocial adjustment (PSA). Mothers and daughters 10-13 YO completed surveys reporting their PSA and perceptions of breast cancer risk. We used linear and logistic regressions with variable selection. Results: 731 parents/guardians reported on their own and the PSA of 898 daughters (450 FH+, 448 FH-), and 447 girls (10-13 YO) completed surveys (227 FH+, 220 FH-). FH+ girls have lower somatization and internalizing behaviors by parent/guardian report than FH- girls (Table 1). Intrusive BC (IBC) worry, and avoidant BC (ABC) worry were significantly higher in FH+ girls. IBC worry (coef=0.8, p=0.04) and ABC worry (coef 1.8, p=0.007) were higher in daughters whose mother had BC. Daughter perceived stress (PS), anxiety, depression, somatization, and internalizing did not differ by mother BC history. In multivariable models, daughter-anxiety was associated with mother-anxiety (Coef 1.4, p<0.0001) and BRCA+ family (coef -13.5, p=0.040). Daughter-depression was associated with mother-anxiety (coef 1.0, p=0.009). Daughter-IBC worry was associated with mother-IBC worry (coef 0.2, p<0.001). Daughter-ABC worry was associated with mother-IBC worry (coef 0.2, p=0.002) and being FH+ (coef 1.3, p=0.02). Daughter-PS was associated with mother-depression (coef 0.2, p=0.003). Somatization was not associated with any variables in multivariable models. FH+ girls were more likely to report themselves at higher risk for BC, although many reported uncertainty about their own BC risk. Table 1Daughter Psychosocial AdjustmentFH+ Mean(SD)FH-Mean(SD)By parent/guardian reportn=437n=431Anxiety46.7 (30.3)49.1 (29.1)Depression51.2 (27.2)52.8 (27.3)Somatization43.9 (30.7)**50.3 (30.7)**Internalizing46.1 (29.6)*50.8 (29.1)*Daughter reportedn=228n=222Anxiety40.2 (28.5)42.4 (29.5)Depression32.4 (26.2)32.4 (27.7)Somatization36.5 (25.5)44.0 (27.7)Internalizing33.1 (25.5)34.0 (26.7)IBC Worry2.0 (3.4)**1.2 (2.4)**ABC Worry3.8 (5.8)**2.0 (4.3)**Perceived Stress4.8 (2.8)4.6 (2.8)Daughter Perceived BC Riskn=219n=209Higher risk for BC than peers85 (39%)**27 (13%)**Same risk as peers57 (26%)54 (26%)Lower risk than peers19 (9%)35 (17%)Responded 'not sure'58 (26)93 (45)* p<0.05, ** p<0.01 Conclusions: Pre-adolescent girls from BC families have lower somatization and internalizing behaviors by parent report, but higher self-reported BC worry. Daughter general anxiety, depression and BC worry are associated with corresponding mother affect. Some girls from BC families are aware of their increased risk and related research suggests this may increase with age. Understanding how PSA and BC worry changes over time and the impact on health and risk behaviors can inform interventions to optimize responses to growing up in families at familial and genetic risk for breast cancer. Citation Format: Angela R Bradbury, Linda Patrick-Miller, Brian Egleston, Lisa Schwartz, Colleen B Sands, Wendy Chung, Gord Glendon, Lisa Tuchman, Cindy Moore, Paula Rauch, Irene Andrulis, Saundra Buys, Caren J Frost, Esther M John, Theresa Keegan, Julia Knight, Mary Beth Terry, Mary Daly. Psychosocial adjustment, cancer worry and perceived risk in 6-13 year old girls from breast cancer families [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P6-10-17.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".