SP222REDUCTION IN ACUTE KIDNEY INJURY (AKI) STAGE IS A STRONG PREDICTOR OF SURVIVAL IN PATIENTS WITH HEPATORENAL SYNDROME TYPE-1 (HRS-1) TREATED WITH TERLIPRESSIN PLUS ALBUMIN OR ALBUMIN ALONE
Bibliographic record
Abstract
Introduction and Aims: HRS-1 is a form of acute kidney injury (AKI) that occurs in patients with end-stage liver disease (ESLD). It is a serious complication that is often fatal if not treated. For AKI in general, it is well established that an increase in AKI stage (using the AKI Network classification), is associated with decreased survival. Conversely, data examining improvement of renal function (i.e. a decrease in AKI stage) and its correlation with survival is limited, particularly in HRS-1. The purpose of this study was to evaluate the impact of changes in AKI stage on survival in patients with HRS-1 in the REVERSE study, the largest, prospective, randomized trial of terlipressin plus albumin vs. albumin alone in cirrhotic patients with HRS-1. Methods: 196 subjects with well documented HRS-1, based on International Ascites Club (IAC) criteria were enrolled; baseline AKI stage was determined using serial serum creatinine (SCr) values collected as part of the pre-enrollment assessment. Subjects were randomized to receive terlipressin (1 mg IV every 6 hours) or placebo, plus albumin. Change in AKI stage from baseline to end of study treatment (EOT) and overall survival at Day 90 were evaluated.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".