Abstract 9518: Role for Mir-126 in Right Ventricle Failure in Pulmonary Arterial Hypertension
Bibliographic record
Abstract
Rationale: Pulmonary arterial hypertension (PAH) is characterized by 1) pulmonary vascular lesions leading to increased pulmonary vascular resistance; 2) right ventricle (RV) microcirculation rarefaction contributing to its failure and 3) decrease skeletal muscle perfusion sustaining exercise intolerance. There is growing evidence that impaired angiogenesis could be a common denominator to this triad of abnormalities. An impaired endothelial function is recognized as the major trigger for PAH, although the mechanism remains unclear. MicroRNAs have emerged as major players in PAH pathogenesis. Thus we hypothesized that miR-126, an endothelial-specific pro-angiogenic microRNA is downregulated in PAH contributing to the pulmonary, RV and skeletal muscle abnormalities. Methods and Results: By qRT-PCR, we showed that miR-126 is down regulated in lungs, RV and skeletal muscles of PAH patients (n=10 to 20; p<0.01) compared to non-PAH donors. This correlates with a reduction of microcirculation (CD31 staining; p<...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".