1742Impact of Material and Social Seprivation on Serogroup B Invasive Meningococcal Disease (IMD-B) Incidence and Outcomes in the Province of Quebec, Canada
Bibliographic record
Abstract
Background. The objective of this work was to assess the social pattern of serogroup B invasive meningococcal disease (IMD-B) incidence and outcomes in the province of Quebec, Canada. Methods. Medical records of laboratory confirmed cases of IMD-B between 1997 and 2010 in the province of Quebec were reviewed through a standardized questionnaire. Social and material deprivation index within the Province of Quebec, by quintile, was assigned to each patient according to postal code of residence. The incidence of IMD-B according to social and material deprivation index was calculated, and the effect of deprivation on the risks of acute complication, major sequelae in survivors and fatal outcome were assessed using logistic regression. Results. Over the 14 year period, 571 cases were identified. Deprivation index were assigned for 527 cases. Incidence rate, by quintile of material deprivation, ranged from 0.31 to 0.54/100,000 person-years, with the lowest incidence found for the most affluent quintile and the highest for the most deprived quintile (P < 0.0001). Among infants <1 year-old and children 1-14 year-old, incidence rates were respectively 3.5 and 2.5 times higher in the most materially deprived quintile than in the most affluent quintile (P = 0.0002 and P = 0.002 respectively). The risk of major sequelae rose with level of material deprivation index and the association was statistically significant (OR = 1.20, 95%CI: 1.01 -1.43, P = 0.04). It rose with level of social deprivation index but was not statistically significant (OR = 1.10, 95%CI: 0.93-1.30, P = 0.28). No association with material and social deprivation was found for acute complication and fatal outcome. Conclusion. In the Province of Quebec, material deprivation is associated with higher incidence rates of IMD-B and higher risk of major sequelae, but not with risk of acute complication or risk of death. Social deprivation does not seem to play a significant role. Disclosures. P. De Wals, GSK: Research Contractor, Research grant; Novartis: Research Contractor, Research grant; Sanofi Pasteur: Research Contractor, Research grant; Pfizer: Research Contractor, Research grant; Health Canada: Research Contractor and Scientific Advisor, Research grant; Quebec Ministry of Health and Social Services: Research Contractor and Scientific Advisor, Research grant
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".