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Record W2215458091 · doi:10.1038/ng.3341

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

2015· article· en· W2215458091 on OpenAlexaff
Erica J. Childs, Evelina Mocci, Daniele Campa, Paige M. Bracci, Steven Gallinger, Michael Goggins, Donghui Li, Rachel Ε. Neale, Sara H. Olson, Ghislaine Scélo, Laufey T. Ámundadóttir, William R. Bamlet, Maarten F. Bijlsma, Amanda L. Blackford, Michael Borges, Paul Brennan, Hermann Brenner, H. Bas Bueno‐de‐Mesquita, Federico Canzian, Gabriele Capurso, Giulia Martina Cavestro, Kari G. Chaffee, Stephen J. Chanock, Sean P. Cleary, Michelle Cotterchio, Lenka Foretová, Charles S. Fuchs, Niccola Funel, Maria Gazouli, Manal M. Hassan, Joseph M. Herman, Ivana Holcátová, Elizabeth A. Holly, Robert N. Hoover, Vladimí­r Janout, Timothy J. Key, Juozas Kupčinskas, Robert C. Kurtz, Stefano Landi, Lingeng Lu, Ewa Małecka‐Panas, Andrea Mambrini, Beatrice Mohelníková-Duchoňová, John P. Neoptolemos, Ann L. Oberg, Irene Orlow, Claudio Pasquali, Raffaele Pezzilli, Cosmeri Rizzato, Amethyst Saldia, Aldo Scarpa, Rachael Z. Stolzenberg‐Solomon, Oliver Strobel, Francesca Tavano, Yogesh K. Vashist, Pavel Vodička, Brian M. Wolpin, Herbert Yu, Gloria M. Petersen, Harvey A. Risch, Alison P. Klein

Bibliographic record

VenueNature Genetics · 2015
Typearticle
Languageen
FieldMedicine
TopicPancreatic and Hepatic Oncology Research
Canadian institutionsPublic Health OntarioCancer Care OntarioPrincess Margaret Cancer CentreUniversity of TorontoUniversity Health NetworkLunenfeld-Tanenbaum Research InstituteMount Sinai Hospital
FundersNational Center for Advancing Translational SciencesNational Cancer InstituteCancer Research UKNational Institutes of HealthNational Center for Chronic Disease Prevention and Health PromotionNational Heart, Lung, and Blood InstituteNational Institute for Health and Care ResearchWorld Health Organization
KeywordsPancreatic cancerPenetranceOdds ratioBiologyPALB2CancerInternal medicineConfidence intervalGenome-wide association studyOncologyGeneticsBioinformaticsGenotypeMutationMedicineSingle-nucleotide polymorphismGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.499

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.357
Teacher spread0.325 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations270
Published2015
Admission routes1
Has abstractno

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