Dietary gangliosides modulate lipid composition in young rat testis
Bibliographic record
Abstract
This study was to investigate if dietary gangliosides alter the lipid‐constituents in rat testis. Weanling male Sprague‐Dawley rats (~37.2g) were fed for 2 weeks diets containing gangliosides (0.1% w/w) and compared animals fed the same diet without gangliosides. Lipids were extracted from whole testis after decapsulation. The level of total and individual gangliosides, cholesterol and fatty acids in phosphatidylcholine (PC) were measured. Rats fed the ganglioside diet exhibited increased total ganglioside content (p<0.02) in testis and a 16% reduction in total cholesterol content (p<0.05) resulting in a decrease in ratio of cholesterol to ganglioside in testis. The major gangliosides in testis were GD1a, GT1b, GM3, and GM1 (30%, 21%, 16% and 14% of total gangliosides, respectively), but no difference in ganglioside composition was observed between dietary treatment. C20:4n‐6 and C22:5n‐6 increased in PC while C18:0 decreased in animals fed the diet containing gangliosides. These results demonstrate that dietary gangliosides may modulate lipid composition in developing rat testis. The influence on production of testosterone is not known. (supported by the University of Manitoba Start‐up Funds).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".