Postalkylation of a Common mPEG-<i>b</i>-PAGE Precursor to Produce Tunable Morphologies of Spheres, Filomicelles, Disks, and Polymersomes
Bibliographic record
Abstract
The facile synthesis of biocompatible materials that self-assemble into nanostructures of well-defined morphology is of keen interest to the biomedical community. Herein, we report on the use of methoxypoly(ethylene glycol)- b -poly(allyl glycidyl ether) (mPEG- b -PAGE) as a platform to generate a series of copolymers derivatized with pendant alkyl chains via thiol–ene click chemistry. Depending on the nature of their hydrophobic block and method of preparation, these amphiphilic block copolymers self-assemble in aqueous solution to form aggregates with distinct and unique morphologies. Spheres, long filomicelles, rods, disks and polymersomes with confirmed biocompatibility were formed from this series of copolymers. These materials hold great promise for use in biomedical applications such as drug delivery.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".