MétaCan
Menu
Back to cohort
Record W2227148039 · doi:10.1038/ng.3374

A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer

2015· article· en· W2227148039 on OpenAlexaff
Folefac Aminkeng, Amit P. Bhavsar, Henk Visscher, Shahrad R. Rassekh, Yuling Li, Jong Wook Lee, Liam R. Brunham, Huib N. Caron, Elvira C van Dalen, Leontien C.M. Kremer, Helena J. H. van der Pal, Ursula Amstutz, Michael Rieder, Daniel Bernstein, Bruce Carleton, Michael R. Hayden, Colin J.D. Ross, Stuart MacLeod, Anne Smith, Claudette Hildebrand, Reza Ghannadan, Fudan Miao, Michelle Higginson, Nasim Massah, Adrienne E. Borrie, Shevaun Hughes, Kaitlyn Shaw, Satvir Dhoot, Kaarina Kowalec, Jessica Stortz, Tessa Bendyshe-Walton, Duncan Waltrip, Rachel Bader, Cheri Nijssen‐Jordan, David W. Johnson, Linda Verbeek, Rick Kaczowka, Patti Stevenson, Carnation Zhuwaki, Paul Grundy, Kent Stobart, Bev Wilson, Sunil Desai, Maria Spavor, L. J. C. Churcher, Terence Chow, Kevin Hall, Nick Honcharik, Sara J. Israels, Shanna Chan, Byron Garnham, Michelle Staub, Geert ‘t Jong, Becky Malkin, Carol Portwine, Amy Cranston, Gideon Koren, Shinya Ito, Paul C. Nathan, Mark Greenberg, Facundo García‐Bournissen, Miho Inoue, Sachi Sakaguchi, Toshihiro Tanaka, Hisaki Fujii, Mina Ogawa, Ryoko Ingram, Taro Kamiya, Smita Karande, Sholeh Ghayoori, Mariana Silva, Stephanie Willing, Régis Vaillancourt, Donna L. Johnston, Herpreet Mankoo, Elaine Wong, Brenda Wilson, Lauren O’Connor, Caleb Hui, Cindy Yuen, Jean‐François Bussières, Denis Lebel, Pierre Barret, Aurélie Clauson, Ève Courbon, L. Cerruti, Nada Jabado, Anelise Espirito Santo, M. CHRISTINE NAGY, Margaret Murray, Darlene Boliver, Marilyn Tiller, C. K. Osborne, Lisa Goodyear, Lynette Bowes, Norma Kean, Jack Hand

Bibliographic record

VenueNature Genetics · 2015
Typearticle
Languageen
FieldMedicine
TopicChemotherapy-induced cardiotoxicity and mitigation
Canadian institutionsJaneway Children's Health and Rehabilitation CentreMcGill University Health CentreCentre Hospitalier Universitaire Sainte-JustineKingston General HospitalMcMaster Children's HospitalLondon Health Sciences CentreHealth Sciences CentreChildren's Hospital of Eastern OntarioBC Children's HospitalIzaak Walton Killam Health CentreStollery Children's HospitalAlberta Children's HospitalMontreal Children's HospitalWestern UniversityChild and Family Research InstituteHospital for Sick ChildrenUniversity of British Columbia
FundersNational Heart, Lung, and Blood Institute
KeywordsBiologyCardiotoxicityAnthracyclineCancer researchChildhood cancerGeneticsCancerCoding (social sciences)OncologyInternal medicineChemotherapyBreast cancerMedicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.014

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.030
GPT teacher head0.335
Teacher spread0.305 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations275
Published2015
Admission routes1
Has abstractno

Explore more

Same venueNature GeneticsSame topicChemotherapy-induced cardiotoxicity and mitigationFrench-language works237,207