A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: Bench or experimentalConsensus signal: Bench or experimental
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.225
- Threshold uncertainty score
- 0.962
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.305 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
The record
- Venue
- Nature Genetics
- Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Field
- Medicine
- Canadian institutions
- Janeway Children's Health and Rehabilitation CentreMcGill University Health CentreCentre Hospitalier Universitaire Sainte-JustineKingston General HospitalMcMaster Children's HospitalLondon Health Sciences CentreHealth Sciences CentreChildren's Hospital of Eastern OntarioBC Children's HospitalIzaak Walton Killam Health CentreStollery Children's HospitalAlberta Children's HospitalMontreal Children's HospitalWestern UniversityChild and Family Research InstituteHospital for Sick ChildrenUniversity of British Columbia
- Funders
- National Heart, Lung, and Blood Institute
- Keywords
- BiologyCardiotoxicityAnthracyclineCancer researchChildhood cancerGeneticsCancerCoding (social sciences)OncologyInternal medicineChemotherapyBreast cancerMedicine
- Has abstract in OpenAlex
- no