Abstract 19081: 5-lipoxygenase Inhibitor Via-2291 (atreleuton) Reduces Inflammation and Coronary Necrotic Core Plaque and Improves Left Ventricular Function in Patients After an Acute Coronary Syndrome
Bibliographic record
Abstract
Background: The 5-lipoxygenase inhibitor VIA-2291 effectively lowers production of leukotriene metabolites. This study investigates the relations between inflammation, coronary plaque characteristics and left ventricular function in response to treatment with VIA-2291 (Atreleuton) in patients after an acute coronary syndrome (ACS). Methods: Fifty six post-ACS patients who participated in a randomized trial evaluating the effects of VIA-2291 vs. placebo and underwent cardiac computed tomography angiography were studied. Leukotriene E4 (LTE4), high-sensitivity C-reactive protein (hs-CRP), coronary plaque volume (PV) with vulnerable characteristics (Necrotic Core) and left ventricular ejection fraction (LVEF) were measured at baseline and at 6-month follow-up. The relation of changes in LTE4, hs-CRP, PV and LVEF in response to VIA-2291 was analyzed using conditional logistic regression analyses. Results: From baseline to 6 months, after adjustment for risk factors, significant reductions in LTE4, hs-CRP and VP, and an increase in LVEF with VIA-2991 as compared to placebo were noted (p<0.05, Table).After adjustment for risk factors, there were strong associations between the decrease in LTE4, the decrease in necrotic core PV and the increase in LVEF (Table); 71% and 79% of the variance in PV and LVEF was explained by the decrease in LTE4 in response to VIA-2991 (p<0.05). The maximum improvement in LVEF was noted with maximum decrease in LTE4 and PV. Conclusion: This study documented a strong relation between decreases in LTE4, decreases in necrotic core coronary plaque volume and improved LV function in response to VIA-2291.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".