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Advances in Research on Hepatoprotective Activity and Synthesis of Oleanolic Acid Derivatives

2015· article· en· W2228414710 on OpenAlexvenueno aff
Xing Zheng, Qu-Tong Zheng, Shaowei Bo, Xianliang Zeng, Yun Wei, Siqi Lei, Xuan Xiao, Ji‐Chang Xiao, Zongbao Wang

Bibliographic record

VenueJournal of Applied Biopharmaceutics and Pharmacokinetics · 2015
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicNatural product bioactivities and synthesis
Canadian institutionsnot available
Fundersnot available
KeywordsOleanolic acidChemistryPharmacologyTraditional medicineCombinatorial chemistryBiochemistryMedicine

Abstract

fetched live from OpenAlex

Oleanolic acid (3b-hydroxyolean-12-en-28-oic acid) is a pentacyclic triterpenoid compound with a wide spread occurrence throughout the plant kingdom. During the last decade many research articles associated with oleanolic acid have been published. Particularly its hepatoprotective activity has been studied for many years. However, the clinical application of oleanolic acid has been limited by its poor solubility. In order to overcome this disadvantage, various approaches have been sought and many derivatives of oleanolic acid have been designed and synthesized. And some of these analogues show improved pharmacokinetic and pharmacodynamic properties, indicating that it may be promising candidates for the treatment of human liver diseases

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.122
Threshold uncertainty score0.556

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.090
GPT teacher head0.396
Teacher spread0.306 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations13
Published2015
Admission routes1
Has abstractyes

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