In vivo efficacy of lasalocid and pyrimethamine treatments against Anophryoides haemophila, a ciliate pathogen of American lobster Homarus americanus
Bibliographic record
Abstract
Lasalocid and pyrimethamine was administered to American lobsters infected with A. haemophila. Lasalocid was found to be toxic and acute mortality was observed, when administered in vivo in both infected and uninfected lobsters. Pyrimethamine was found very efficient to treat these ciliates at repeated doses. The mortality was very low and the mean haemocyte counts remained higher than the uninfected control group. The drug seems to delay the appearance of the ciliates in the haemolymph and to lower the spread of these parasites in the epipodite and the hepatopancreas. In uninfected animals treated with this drug, haemocyte counts were similar to uninfected control group. Furthermore, no pathology was observed, when the drug was administered to uninfected lobsters. Since there is no effective treatment for the control of bumper car disease, on the basis of the results of the present study, we suggest that pyrimethamine is a good drug for the treatment of A. haemoplila infection in lobsters.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.003 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".