Celiac disease among symptom-free children-more than what is expected
Bibliographic record
Abstract
Sir, We read with interest the study by Al Hatlani[1] on the prevalence of celiac disease among an asymptomatic population of children in the Eastern province of Saudi Arabia. We commend the author on his work and believe that his findings do replicate that of our study.[2] We do have a concern on the reported histological prevalence of celiac disease in the sample population. The author reported that 32 of the 1141 serum samples were positive for celiac, which would indicate a seroprevalence of 2.8%. Only 10 of those who were positive underwent an endoscopy with histological findings that confirmed the serological test. The author suggested that the histologically proven prevalence is only 1%, which implies that the author presumed that the 22 patients that refused endoscopy would have had a negative histology. That presumption would only be true if those that had refused the biopsies were different in any way from those that agreed to undergo duodenal biopsies, which the author did not demonstrate in the manuscript. Furthermore, we know that the test performance of the anti-tissue transglutaminase antibodies have a high sensitivity (95%) and specificity (94%)[3] and most probably if endoscopies had been performed on those who had refused, the serological and histological prevalence would have been similar. Also, the author suggested that screening for celiac disease should be undertaken. We argue that such a strategy is not so clear and there are arguments that go against that recommendation including the age of initiation of serological screening and whether treating asymptomatic patients changes the natural history of the disease.[4] So at least we would say that such a statement is open to debate. In addition we wanted to point out that the study by Aljebreen et al.[2] was conducted on a population of adolescents that were attending schools in different regions of the kingdom thus the author's statement that his study would be the first of its kind would be inaccurate. Again we commend the author on his effort and believe that his study has an added value to the region. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".