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Record W2238050425 · doi:10.1038/npjgenmed.2015.1

Genomic medicine goes mainstream

2016· editorial· en· W2238050425 on OpenAlexaff
Stephen W. Scherer

Bibliographic record

Venuenpj Genomic Medicine · 2016
Typeeditorial
Languageen
FieldMedicine
TopicPrenatal Screening and Diagnostics
Canadian institutionsUniversity of TorontoHospital for Sick ChildrenSickKids Foundation
Fundersnot available
KeywordsMainstreamGenomic medicineBiologyComputational biologyPolitical scienceLaw

Abstract

fetched live from OpenAlex

I believe that we will look back upon 2015 as the year when whole-genome sequencing (WGS) went mainstream, and the concept of genomic medicine started to move into broad practical application. Each human genome is a blueprint, sculpted by millennia of natural selection, and individualised through meiosis. Its decoding will enable formulated health-related decisions that will become an increasing part of our daily existence.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.016
metaresearch head score (Gemma)0.073
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: Editorial
Teacher disagreement score0.051
Threshold uncertainty score0.085

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0160.073
Meta-epidemiology (narrow)0.0040.002
Meta-epidemiology (broad)0.0050.003
Bibliometrics0.0050.002
Science and technology studies0.0070.012
Scholarly communication0.0180.014
Open science0.0050.007
Research integrity0.0510.068
Insufficient payload (model declined to judge)0.0150.011

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.287
Teacher spread0.273 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2016
Admission routes1
Has abstractno

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