Cerebrovascular Response to CO2 Following 10 Days of Intermittent Hypoxia in Humans
Bibliographic record
Abstract
INTRODUCTION: It has been demonstrated that the cerebrovascular response to hypoxia is blunted following 10 d of intermittent hypoxia (IH) in healthy humans. The purpose of this study was to test the hypothesis that IH reduces the cerebrovascular response to CO2. METHODS: Healthy male subjects (N=8; 25±2 yr) were exposed to 10 consecutive days of IH (12% O2 for 5 min followed by 5 min of normoxia for 1 h/d). The cerebrovascular response to CO2 was assessed prior to (PRE-IH) and following (POST-IH) the IH paradigm with transcranial Doppler ultrasound. RESULTS: There was no change in eupnic measures during or following the IH paradigm; however, the ventilatory response to IH increased by the last exposure (3.0±2.8 L·min(-1)). Cerebral blood flow velocity decreased and increased with hypocapnia and hypercapnia, respectively, but cerebrovascular sensitivity to CO2 remained unchanged with IH (PRE-IH: 2.58±0.50%/mmHg; POST-IH: 2.59±0.74%/mmHg). DISCUSSION: Our data indicates that 10 d of IH in healthy humans does not alter the cerebrovascular response to CO2. Redundancy of cerebrovascular regulation mechanisms to CO2 may work to counteract IH-induced dysregulation and protect cerebral tissue.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".