Reactions for the functionalization of the lower rim of calix[4]resorcinarenes and synthesis of eta6-[1,3-bis-(2'4 '6'-trimethoxybenzyl)benzene]tricarbonylchromium.
Bibliographic record
Abstract
In this project, the intent was to design and synthesize a calixresorcinarene that has a cleft in the tail of the molecule and would serve in molecular recognition processes. Calix[4]resorcinarene (79) was prepared and treated with NBS and Me2SiCl2 to obtain a bridged resorcinarene (82) with a rigid cavity and to protect the phenol groups at the top rim of the molecule. Many reactions were tried on 82 in order to functionalize the pendant groups at the rear end of the molecule, but none of the conditions met with success. Compound 82 was soluble only in DMF, therefore all the reactions were performed in that solvent. This limitation may have influenced the outcome of the reactions. The synthesis of basic cyclophane frameworks very similar to calixarene molecules was also studied in this project. Chromium complexes of m-xylene-alpha, alpha'-diol (91) and 5-amino-1,3-hydroxymethylbenzene (96) were synthesized and then reacted with trimethoxybenzene (92). No product was identified from the reaction of 91, but the chromium complex of 1,3-bis-(2 ',4',6'-trimethoxybenzyl) benzene (93) was obtained and fully characterized. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis2001 .M348. Source: Masters Abstracts International, Volume: 40-06, page: 1527. Adviser: P. J. Dutton. Thesis (M.Sc.)--University of Windsor (Canada), 2001.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".