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Record W2243137028

La nifédipine (Adalate®) augmente la mortalité chez le sujet âgé

2000· article· fr· W2243137028 on OpenAlexaboutno aff
B Rouveix

Bibliographic record

VenueMédecine thérapeutique · 2000
Typearticle
Languagefr
FieldMedicine
TopicPharmaceutical Practices and Patient Outcomes
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineNifedipineGynecologyDiltiazemInternal medicineCalcium
DOInot available

Abstract

fetched live from OpenAlex

Cette observation a ete faite par une equipe canadienne au decours d'une etude portant sur 837 sujets hypertendus âges (moyenne d'âge : 80,4 ans) traites pendant 5 ans par nifedipine, diltiazem, verapamil, diuretiques de l'anse, beta-bloqueurs, inhibiteurs de l'enzyme de conversion ou anti-hypertenseurs. Le risque de mortalite est apparu significatif pour la nifedipine (1,82 ; CI 95 % : 1,09-3,04) compare aux beta-bloquants. Ce risque etait plus eleve pour les fortes doses : 2,19 (1,19-4,03) au-dela de 40 mg/j et 1,50 (0,74-3,02) en deca de 30 mg/j. Le risque est majore par d'autres facteurs comme l'usage d'une forme retard et le debut du traitement. A suivre.Maxwell C.J., et al. 2000. Nifedipine and mortality risk in the elderly : relevance of drug formulation, dose and duration. Pharmacolo-epidemiol. Drug Saf Jan-Fev : 11-23.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.054
GPT teacher head0.366
Teacher spread0.312 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2000
Admission routes1
Has abstractyes

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