Physical and psychological well-being in patients with stage IV GI cancer
Bibliographic record
Abstract
8266 Background: In many cancer centres, referral to palliative care often does not occur until near the end of life, despite substantial disease burden much earlier in the course of the illness. The present longitudinal study is being conducted to evaluate disease burden and its relation to psychological well being in patients with stage IV cancer receiving treatment at a comprehensive cancer center. Methods: Patients with stage IV gastrointestinal (GI) cancer are being recruited to this study from outpatient clinics at Princess Margaret Hospital, Toronto, Canada. Subjects who pass a cognitive screen (Short Orientation-Memory-Concentration Test ≥ 20) are administered self-report measures at 1–2 monthly intervals. These include: The Brief Pain Inventory, The Memorial Symptom Assessment Scale, The Beck Depression Inventory–II, The Beck Hopelessness Scale, The Schedule of Attitudes Towards Hastened Death, The Functional Assessment of Chronic Illness Therapy-Sp-12, and The Rosenberg Self-Esteem Scale. Results: Amongst 115 subjects with stage IV GI cancer recruited thus far (72% participation rate), multiple physical symptoms were common (\(\underline{\mathrm{M}}\)=5.0 ±3.7), including moderate to severe fatigue (52.2%), sleep disturbance (47.8%) and pain (46.1%). Psychological disturbances were also common, including moderate to severe depressive symptoms (20.9%), and hopelessness (26.1%). Pain, the number of physical symptoms, gender, self-reported spirituality and self-esteem together accounted for 53% of the variance in predicting depression (p<.01). Conclusions: Multiple physical symptoms, including significant pain, are common in patients with stage IV GI cancer, and these symptoms are associated with an increased risk of depression. Trials of early multidimensional palliative interventions are needed to determine to what extent these disturbances can be alleviated and quality of life can be improved in patients with stage IV disease. No significant financial relationships to disclose.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".