Abstract 67: Risk of Symptomatic Intracerebral Hemorrhage in Ischemic Stroke Thrombolysis: the SEDAN Score
Bibliographic record
Abstract
Objectives To develop a score for assessing the risk of symptomatic intracerebral hemorrhage (sICH) in ischemic stroke patients treated with iv thrombolysis. Methods The score was derived from a cohort of acute ischemic stroke patients treated with iv thrombolysis (n=972) at the Helsinki University Central Hospital (1995-2008). The predictive value of parameters associated with development of sICH (ECASS-2 criteria) was evaluated, and the score was developed according to the magnitude of logistic regression coefficients. The accuracy of the model was evaluated with 1000 bootstrap replicates. To test the performance of the score, we calculated area under receiver operating characteristic curve (AUC-ROC). We calculated absolute risks and likelihood ratios of sICH per increasing score points. The score was validated externally in merged cohort from 3 Swiss cities (Lausanne, Basel, and Geneva) including 828 ischemic stroke patients treated with iv thrombolysis. Findings The SEDAN score (0 to 6 points) consists of blood S ugar (glucose) at baseline [8.1-12.0 mmol/L (145-216 mg/dL)=1; >12.0 mmol/L (>216 mg/dL)=2], E arly infarct signs (yes=1) and (hyper) D ense cerebral artery sign (yes=1) on admission CT scan, A ge (>75=1), and N IH Stroke Scale on admission (>9=1). Accuracy of the score based on 1000 bootstrap replicates was 93.1% (91.4%-94.5%). AUC-ROC was 0.73 (0.67-0.79; p<0.001). Absolute risk for sICH in patients with increasing score points was: 1.4%, 2.9%, 8.5%, 12.2%, 21.7%, and 33.3% for 0, 1, 2, 3, 4, and 5 score points, respectively. Likelihood ratios were 0.19 (0.06-0.59), 0.40 (0.21-0.76), 1.23 (0.85-1.79), 1.85 (1.26-2.72), 3.68 (2.10-6.45), and 5.66 (2.40-13.40), respectively. Absolute risks in external validation were similar (1.0%, 3.5%, 5.1%, 9.2%, 16.9%, and 27.8%, respectively), and AUC-ROC was 0.77 (0.71-0.83; p<0.001). Conclusions The SEDAN score reliably assesses the risk of sICH in iv thrombolysis treated ischemic stroke patients and can support clinical decision-making in the high-risk patients. External validation of the score in the three Swiss cohorts supports its generalizibility.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".