Pagliaros’ Comprehensive Guide to Drugs and Substances of Abuse
Bibliographic record
Abstract
Drug and substance abuse is a major problem in North America. Health care providers who care for patients who abuse drugs and other substances need to have a clear understanding of the health, societal, and economic impact of this problem and an intimate knowledge of the agents of abuse to ensure adequate treatment. Pagliaros’ Comprehensive Guide to Drugs and Substances of Abuse was written to provide general health care professionals with a timely, authoritative, scholarly, and well-referenced compilation and analysis of available data concerning the status, trends, and pharmacology of drugs and substances of abuse in North America. Following a brief introduction outlining the issues in drugs and substance abuse, the book is divided into two parts. Part 1 consists of three chapters, each devoted to the history and pharmacology of one of the three major classes of drugs and substances. Chapter 1, The Psychodepressants, outlines the opiates, sedative–hypnotics (e.g., alcohol, benzodiazepines, barbiturates) and volatile solvents and inhalants. Chapter 2, The Psychostimulants, covers amphetamines, caffeine, cathinone, cocaine, and nicotine. Chapter 3, The Psychedelics, reviews the indoles (e.g., lysergic acid diethylamide), psilocin, psilocybin), the phenethylamines (e.g., 3,4-methylenedioxyamphetamine [MDA], 3,4-methylenedioxymethamphetamine [MDMA], and mescaline [peyote]), and cannabis (e.g., marijuana, hashish, hashish oil). The pharmacology, pharmacokinetics, pharmacodynamics, adverse effects and toxicity, physical and psychological dependence, patterns of use (medical and personal), and theories of use of each agent are outlined. Part 2 consists of monographs of 96 drugs and substances of abuse. Each monograph contains information on the name or names of drugs or substances of abuse, pharmacologic class, brief overview (including availability and use patterns), available dosage forms, routes of administration, mechanism of action, current approved indications for medical use, desired action or reason for personal use, basic toxicology (including associated acute and chronic adverse effects), teratogenic and fetotoxic potential, signs and symptoms of overdose, withdrawal syndrome, and basic treatment.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".