Retrospective Review of Gonococcal and Chlamydial Cases of Pelvic Inflammatory Disease in Two Canadian STI Clinics, 2004–2014
Bibliographic record
Abstract
Background. Pelvic inflammatory disease (PID) commonly affects women of reproductive age. No Canadian data exists on the treatment and outcomes of gonococcal (GC) and chlamydial (CT) infections complicated by PID. Our study sought to examine cases in two Canadian Sexually Transmitted Infections (STI) Clinics. Methods. GC and CT PID cases reported by the Calgary and Edmonton STI Clinics from January 1, 2004 to September 30, 2014 were reviewed. Clinical criteria for PID diagnosis were cervical motion tenderness ± adnexal tenderness. Improved disposition was defined as no worsening of symptoms at the follow-up visit. Treatment failures were defined as those with persistent symptoms requiring additional treatment and no sexual contact between the start of treatment and follow-up visit. Descriptive analysis was completed using IBM SPSS Statistics version 19.0 (IBM, Armonk, NY). Ethics approval was obtained from the University of Alberta's Health Research Ethics Board. Results. One hundred PID cases were reviewed. The median age of cases was 20 years (IQR: 18-26). Most cases were Caucasian (n = 56) and 6 cases were pregnant. The majority of cases (n = 81) were diagnosed with CT alone, 12 cases with GC alone and 7 cases were co-infected with GC and CT. Co-infections with bacterial vaginosis (n = 32) and trichomoniasis (n = 3) also occurred. Most cases (n = 73) were treated with ceftriaxone 250 mg IM and doxycycline 100 mg bid for 14 days ± metronidazole 500 mg bid for 14 days, 17 cases were treated with ofloxacin 400 mg bid for 14 days ± metronidazole, and the remaining cases (n = 10) were treated with other drug regimens. Over one-half of (n = 58) cases returned for follow-up, of which 10 cases (17.2%) had not improved. Six of the cases that did not improve were due to re-exposure (n = 4), non-adherence (n = 1), and intolerance of medications (n = 1); one case was lost to follow up. The remaining 3 cases were treatment failures; all were treated with ofloxacin, resulting in a 30% treatment failure rate for ofloxacin treated cases who returned for follow-up (3 of 10 cases). Conclusion. The majority of PID cases were treated according to Alberta STI guidelines. All cases treated with ceftriaxone and doxycycline ± metronidazole responded to treatment while all treatment failures were treated initially with ofloxacin. Disclosures. All authors: No reported disclosures.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.008 | 0.012 |
| Science and technology studies | 0.004 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".