Tumour Necrosis Factor Inhibitors and Infection: What Is there to Know for Infectious Diseases Physicians?
Bibliographic record
Abstract
At this year′s meeting of Digestive Disease Week in Los Angeles, California, it was noted that antitumour necrosis factor (anti‐TNF) inhibitors showed further evidence of efficacy in Crohn′s disease (1). TNF antagonists have been used increasingly in the treatment of a number of other inflammatory diseases, especially rheumatoid arthritis (RA), where they have revolutionized treatment (2). At the same time, their use has been associated with an increased risk of serious infections (3). As more patients are treated with these agents, it is inevitable that infectious diseases physicians will see a variety of infections, both common and uncommon, requiring familiarity with this new class of drugs and their infectious complications.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.015 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.004 | 0.005 |
| Scholarly communication | 0.006 | 0.017 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.013 | 0.013 |
| Insufficient payload (model declined to judge) | 0.015 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".