Analysis of the oligomerization propensity of prohibitin1 (603.1)
Bibliographic record
Abstract
Prohibitins (PHB) are highly conserved and ubiquitously expressed proteins in eukaryotic cells. The prohibitin family exist in two isoforms PHB1 (also known as BAP32) and PHB2 ( also known as BAP37 and REA). The PHB1 and PHB2 together form large ring shaped complexes in the inner‐mitochondrial membrane, although PHB has also been reported to be localized in the nucleus and the cell membrane. PHB proteins have been implicated in mitochondrial biogenesis as well as scaffold for mitochondrial proteins. Details on the structure and function of PHB1 are still unclear. To better understand the functional mechanisms of PHB1 , we conducted biophysical analysis on recombinant human PHB1 and a truncated form of PHB1 (aa 52‐197). Our results show that PHB1 variants can form oligomers, and that varying salt concentration can modulate the polymerization of PHB1. Furthermore, addition of iron to PHB1 in solution affects the stability of the PHB1 oligomers. These data suggest that PHB1 could have diverse oligomeric forms depending on its local environment Grant Funding Source : Supported by: Manitoba Health Research Council,
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".