Mechanism by which CA150 inhibits the activities of C/EBPα
Bibliographic record
Abstract
Co‐Activator of 150 kDa (CA150) is a transcription elongation factor, but has also recently been shown by our lab to act as a co‐repressor for CCAAT/enhancer binding protein α (C/EBPα) transcriptional activity. Interestingly, CA150 also inhibits the growth arrest activity of C/EBPα. In this study, we examined domains within CA150 that mediated its inhibitory activity towards C/EBPa and the mechanism whereby this effect occurs. Our structure/function analysis using mutants of CA150 suggest that the inhibitory activity lies within the N‐terminal domain. Additionally, laser‐scanning confocal microscopy was used to visualize the subnuclear localization of fluorescent‐tagged CA150 and C/EBPα. Results show that co‐expression of CA150 influences the intranuclear organization of C/EBPα, suggesting a possible mechanism whereby CA150 inhibits the growth arrest and transcriptional activities of C/EBPα. Funding for this project has been provided by Canadian Institutes of Health Research, Saskatchewan Health, and University of Saskatchewan.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".