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Record W2260092666

Refined Inertias Related to Biological Systems and to the Petersen Graph

2015· dissertation· en· W2260092666 on OpenAlexfundno aff
G.J. Culos

Bibliographic record

VenueUVic’s Research and Learning Repository (University of Victoria) · 2015
Typedissertation
Languageen
FieldNeuroscience
TopicGenetic Neurodegenerative Diseases
Canadian institutionsnot available
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsGraphComputer scienceTheoretical computer science
DOInot available

Abstract

fetched live from OpenAlex

Many models in the physical and life sciences formulated as dynamical systems have a positive steady state, with the local behavior of this steady state determined by the eigenvalues of its Jacobian matrix. The first part of this thesis is concerned with analyzing the linear stability of the steady state by using sign patterns, which are matrices with entries from the set {+,-,0}. The linear stability is related to the allowed refined inertias of the sign pattern of the Jacobian matrix of the system, where the refined inertia of a matrix is a 4-tuple (n+, n_-, ; nz; 2np) with n+ (n_) equal to the number of eigenvalues with positive (negative) real part, nz equal to the number of zero eigenvalues, and 2np equal to the number of nonzero pure imaginary eigenvalues. This type of analysis is useful when the parameters of the model are of known sign but unknown magnitude. The usefulness of sign pattern analysis is illustrated with several biological examples, including biochemical reaction networks, predator{prey models, and an infectious disease model. The refined inertias allowed by sign patterns with specific digraph structures have been studied, for example, for tree sign patterns. In the second part of this thesis, such results on refined inertias are extended by considering sign and zero-nonzero patterns with digraphs isomorphic to strongly connected orientations of the Petersen graph.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0020.001
Science and technology studies0.0000.002
Scholarly communication0.0010.002
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.053
GPT teacher head0.304
Teacher spread0.250 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2015
Admission routes1
Has abstractyes

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